A prospective comparative randomized trial of the efficacy and safety of topical tenoxicam and diclofenac in knee osteoarthritis

Local forms of non-steroidal anti-inflammatory drugs (NSAIDs) are characterized by a high safety profile due to low systemic absorption. They do not increase the risk developing class-specific gastrointestinal, cardiovascular and kidney adverse events (AEs), which makes it possible prescribe them even in severe comorbid pathology, is typical for patients with osteoarthritis (OA). Objective : evaluate efficacy Artoxan gel (tenoxicam) 1% comparison Diclofenac knee OA prospective comparative randomized trial. Material methods . The study included 60 Kellgren–Lawrence stages II–III OA, aged 41 78 years. were randomly divided into two groups: 1st group received 1%, 5 cm 2 times day 14 days; 2nd – according same scheme. During therapy, we assessed pain using visual analog scale, WOMAC index, quality life EQ-5D questionnaire, satisfaction time effect. Results discussion It has been demonstrated that local NSAIDs have positive effect on all clinical manifestations OA: effectively reduce pain, stiffness, improve functional state joints life. also good fast symptomatic response. Comparison groups showed receiving form tenoxicam, there was tendency more rapid pronounced analgesic Conclusion results confirm NSAIDs.